Interictal EEG Spikes Identify Seizure Focus

Predictability of EEG interictal spikes.

To determine whether EEG spikes are predictable, time series of EEG spike intervals were generated from subdural and depth electrode recordings from four patients. The intervals between EEG spikes were hand edited to ensure high accuracy and eliminate false positive and negative spikes. Spike rates (per minute) were generated from longer time series, but for these data hand editing was usually ...

Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients.

PURPOSE The role of sharps and spikes, interictal epileptiform discharges (IEDs), in guiding epilepsy surgery in children remains controversial, particularly with intracranial electroencephalography (IEEG). Although ictal recording is the mainstay of localizing epileptic networks for surgical resection, current practice dictates removing regions generating frequent IEDs if they are near the ict...

Source Analysis of Interictal Spikes in EEG and MEG

Simultaneous EEG/MEG and ECoG source characterization of interictal spikes

For some TLE patients that do not respond the pharmacological treatment, epilepsy surgery is an option. In those cases, the determination of the location of the sources and the sequence in which they become active is of prime importance. In this paper, we investigate the interpretability and validity of dipole source localization based on EEG, MEG and simultaneous EEG+MEG for TLE interictal spi...

Nonlinear EEG analysis in epilepsy: its possible use for interictal focus localization, seizure anticipation, and prevention.

Several recent studies emphasize the high value of nonlinear EEG analysis particularly for improved characterization of epileptic brain states. In this review the authors report their work to increase insight into the spatial and temporal dynamics of the epileptogenic process. Specifically, they discuss possibilities for seizure anticipation, which is one of the most challenging aspects of epil...